FITC标记的甲基化CpG结合蛋白3抗体
产品名称： FITC标记的甲基化CpG结合蛋白3抗体
英文名称： Anti-MBD3/FITC
产品编号： HZ-18699R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-MBD3/FITC Conjugated antibody
FITC标记的甲基化CpG结合蛋白3抗体
| 英文名称 | Anti-MBD3/FITC |
| 中文名称 | FITC标记的甲基化CpG结合蛋白3抗体 |
| 别 名 | AI181826; AU019209; MBD 3; Mbd3; MBD3: methyl CpG binding domain protein 3; MBD3_HUMAN; Methyl CpG binding domain protein 3; Methyl CpG binding protein MBD3; Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 结合蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 33kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MBD3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] Function: Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Subunit: Heterodimer with MBD2. Part of the NuRD and the MeCP1 complex. Interacts with BCL6, HDAC1, MTA2, DNMT1, p66-alpha and p66-beta. Subcellular Location: Nucleus. Chromosome. Note: Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes. Similarity: Contains 1 MBD (methyl-CpG-binding) domain. Database links: Entrez Gene: 53615 Human Entrez Gene: 17192 Mouse Entrez Gene: 362834 Rat Entrez Gene: 398135 Xenopus laevis Omim: 603573 Human SwissProt: O95983 Human SwissProt: Q9Z2D8 Mouse Unigene: 178728 Human Unigene: 7142 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
DNA甲基化是真核基因组的主要修饰，在哺乳动物的发育过程中起着至关重要的作用。该基因属于一个核蛋白家族，其特征在于存在甲基CpG结合结构域（MD）。编码蛋白是NuRD的一个亚基，NuRD是一个多亚基复合物，包含核小体重塑和组蛋白脱乙酰酶活性。与其他家族成员不同，编码的蛋白质不能与甲基化DNA结合。蛋白质介导转移相关蛋白2与核心组蛋白去乙酰化酶复合物的结合。选择性剪接导致该基因的多个转录变体。[ RefSeq，JUL 2013 ]