PPP1CA (N-term) Peptide
产品名称： PPP1CA (N-term) Peptide
英文名称： PPP1CA (N-term) Peptide
产品编号： P3319
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PPP1CA.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human PPP1CA.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1.
Zhou G, Boomer JS, Tan TH.J Biol Chem. 2004 Nov 19;279(47):49551-61. Epub 2004 Sep 13.
- 2.
- Dephosphorylation of histone gamma-H2AX during repair of DNA double-strand breaks in mammalian cells and its inhibition by calyculin A.
Nazarov IB, Smirnova AN, Krutilina RI, Svetlova MP, Solovjeva LV, Nikiforov AA, Oei SL, Zalenskaya IA, Yau PM, Bradbury EM, Tomilin NV.Radiat Res. 2003 Sep;160(3):309-17.
- 3.
- Nuclear protein phosphatase-1 regulates HIV-1 transcription.
Ammosova T, Jerebtsova M, Beullens M, Voloshin Y, Ray PE, Kumar A, Bollen M, Nekhai S.J Biol Chem. 2003 Aug 22;278(34):32189-94. Epub 2003 Jun 4.
- Applications
- Western Blot (Tissue lysate)
- Western blot analysis of PPP1CA polyclonal antibody (Cat # PAB4164) in mouse heart tissue lysate (35 ug/lane). PPP1CA (arrow) was detected using the purified polyclonal antibody (1 : 60 dilution).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human breast cancer tissue reacted with PPP1CA polyclonal antibody (Cat # PAB4164) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 5499
- Protein Accession#:
- NP_002699;P62136
- Gene Name:
- PPP1CA
- Gene Alias:
- MGC15877,MGC1674,PP-1A,PPP1A
- Gene Description:
- protein phosphatase 1, catalytic subunit, alpha isoform
- Omim ID:
- 176875
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- protein phosphatase 1, catalytic subunit, alpha,serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit