SENP3 polyclonal antibody
产品名称： SENP3 polyclonal antibody
英文名称： SENP3 polyclonal antibody
产品编号： PAB2416
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of SENP3.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human SENP3.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- SP-RING for SUMO: new functions bloom for a ubiquitin-like protein.
Hochstrasser M.Cell. 2001 Oct 5;107(1):5-8.
- 2.
- Involvement of PIAS1 in the sumoylation of tumor suppressor p53.
Kahyo T, Nishida T, Yasuda H.Mol Cell. 2001 Sep;8(3):713-8.
- 3.
- SUMO, ubiquitin's mysterious cousin.
Muller S, Hoege C, Pyrowolakis G, Jentsch S.Nat Rev Mol Cell Biol. 2001 Mar;2(3):202-10.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of SENP3 polyclonal antibody (Cat # PAB2416) in SAOS-2 cell lysate. SENP3 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- (LEFT) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the SENP3 polyclonal antibody (Cat # PAB2416) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. (RIGHT) Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with SENP3 polyclonal antibody (Cat # PAB2416) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.
- Entrez GeneID:
- 26168
- Protein Accession#:
- NP_056485;Q9H4L4
- Gene Name:
- SENP3
- Gene Alias:
- DKFZp586K0919,DKFZp762A152,SMT3IP1,SSP3
- Gene Description:
- SUMO1/sentrin/SMT3 specific peptidase 3
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM
- Other Designations:
- SUMO1/sentrin/SMT3 specific protease 3,sentrin/SUMO-specific protease 3