PIN1 polyclonal antibody
产品名称： PIN1 polyclonal antibody
英文名称： PIN1 polyclonal antibody
产品编号： PAB8979
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PIN1.
- Immunogen:
- A synthetic peptide corresponding to N-terminus amino acids 53-73 of human PIN1 and mouse Pin1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Storage Buffer:
- In buffer containing 0.02% sodium azide
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:10000)
Western Blot (1:500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy.
Lim J, Balastik M, Lee TH, Nakamura K, Liou YC, Sun A, Finn G, Pastorino L, Lee VM, Lu KP.J Clin Invest. 2008 May;118(5):1877-89.
- 2.
- Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity.
Barone MC, Desouza LA, Freeman RS.J Neurochem. 2008 Jul;106(2):734-45. Epub 2008 Apr 14.
- 3.
- Pin1 interacts with c-Myb in a phosphorylation-dependent manner and regulates its transactivation activity.
Pani E, Menigatti M, Schubert S, Hess D, Gerrits B, Klempnauer KH, Ferrari S.Biochim Biophys Acta. 2008 Jun;1783(6):1121-8. Epub 2008 Mar 5.
- Application Image
- Western Blot
- ELISA
- Entrez GeneID:
- 5300
- Gene Name:
- PIN1
- Gene Alias:
- DOD,UBL5
- Gene Description:
- peptidylprolyl cis/trans isomerase, NIMA-interacting 1
- Omim ID:
- 601052
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The human PIN1 gene encodes an essential nuclear peptidylprolyl cis-trans isomerase (PPIase; EC 5.2.1.8) involved in regulation of mitosis. PIN1 belongs to a class of PPIases that includes the E. coli parvulin, yeast Ess1, and Drosophila dodo (dod) gene products (Lu et al., 1996 [PubMed 8606777]).[supplied by OMIM
- Other Designations:
- peptidyl-prolyl cis/trans isomerase, NIMA-interacting,prolyl isomerase,protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1,protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1