FITC标记的唾液酸结合免疫球蛋白样凝集素9抗体
产品名称： FITC标记的唾液酸结合免疫球蛋白样凝集素9抗体
英文名称： Anti-SIGLEC9/FITC
产品编号： HZ-9874R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-SIGLEC9/FITC Conjugated antibody
FITC标记的唾液酸结合免疫球蛋白样凝集素9抗体
| 产品编号 | bs-9874R-FITC |
| 英文名称 | Anti-SIGLEC9/FITC |
| 中文名称 | FITC标记的唾液酸结合免疫球蛋白样凝集素9抗体 |
| 别 名 | CD329; CDw329; OB binding protein like; OBBP LIKE; Protein FOAP 9; Protein FOAP-9; sialic acid binding Ig like lectin 9; Sialic acid-binding Ig-like lectin 9; Sialic acid-binding immunoglobulin like lectin 9; SIGL9_HUMAN; Siglec 9; Siglec-9; SIGLEC9. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 免疫学 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 50kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SIGLEC9 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Two families of mammalian lectin-like adhesion molecules bind glycoconjugate ligands in a sialic acid-dependent manner: the selectins and the sialoadhesins. The sialic acid-binding immunoglobulin superfamily lectins, designated siglecs or sialoadhesins, are immunoglobulin superfamily members recognizing sialylated ligands. The common sialic acids of mammalian cells are N-acetyl-neuraminic acid (Neu5Ac) and N-glycolyl-neuraminic acid (Neu5Gc). Siglec-1 mediates local cell-cell interactions in lymphoid tissues and can be detected at contact points of macrophages with other macrophages, sinus-lining cells and reticulum cells. Siglec-7, highly expressed in monocytes and resident blood cells, but not in parenchymatous cells, mediates inhibition of natural killer cell cytotoxicity. Siglec-9 is closely homologous to Siglec-7; the gene encoding it maps to chromosome 19q13.41 in humans. It is highly expressed in peripheral blood leukocytes (but not eosinophils), liver, bone marrow, placenta and spleen. Siglec-8, a type I membrane protein, is selectively expressed on human eosinophils, basophils and mast cells, where it regulates their function and survival. Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Subcellular Location: Membrane. Tissue Specificity: Expressed by peripheral blood leukocytes (neutrophils and monocytes but not eosinophils). Found in liver, fetal liver, bone marrow, placenta, spleen and in lower levels in skeletal muscle, fetal brain, stomach, lung, thymus, prostate, brain, mammary, adrenal gland, colon, trachea, cerebellum, testis, small intestine and spinal cordon. Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Database links: Clone ID: AAF87223 Human Entrez Gene: 27180 Human Omim: 605640 Human SwissProt: Q9Y336 Human Unigene: 245828 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
两个哺乳动物凝集素样粘附分子家族以唾液酸依赖的方式结合糖缀合配体：选择素和唾液酸粘附素。唾液酸结合免疫球蛋白超家族凝集素，命名为SigCels或唾液酸粘附素，是识别唾液酸配体的免疫球蛋白超家族成员。哺乳动物细胞中常见的唾液酸是N-乙酰神经氨酸（NY5AC）和N-乙醇基-神经氨酸（NY5GC）。SigCel-1介导了淋巴组织中的局部细胞-细胞相互作用，并可在巨噬细胞与其他巨噬细胞、窦内衬细胞和网织细胞的接触点处检测到。SigCel-7在单核细胞和常驻血细胞中高表达，但在实质细胞中不表达，介导天然杀伤细胞毒性的抑制。SigCel-9与SigCel-7密切相关；编码的基因在人类中映射到染色体19q1341。它在外周血白细胞（而不是嗜酸性粒细胞）、肝脏、骨髓、胎盘和脾脏中高表达。SigCel-8是一种I型膜蛋白，选择性地在人嗜酸性粒细胞、嗜碱性粒细胞和肥大细胞上表达，并调节其功能和存活。