FITC标记的神经细胞分化相关蛋白AHNAK抗体
产品名称： FITC标记的神经细胞分化相关蛋白AHNAK抗体
英文名称： Anti-AHNAK/FITC
产品编号： HZ-13624R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-AHNAK/FITC Conjugated antibody
FITC标记的神经细胞分化相关蛋白AHNAK抗体
| 英文名称 | Anti-AHNAK/FITC |
| 中文名称 | FITC标记的神经细胞分化相关蛋白AHNAK抗体 |
| 别 名 | AHNAK; AHNAK nucleoprotein (desmoyokin); AHNAKRS; AHNK_HUMAN; Desmoyokin; Fragments; MGC5395; Neuroblast differentiation associated protein AHNAK; Neuroblast differentiation-associated protein AHNAK; PM227. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 神经生物学 细胞分化 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 629kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human AHNAK |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: AHNAK is a 5,890 amino acid protein encoded by the human gene AHNAK. The intronless AHNAK gene is located on human chromosome 11q12 and has three main structural regions: the 251 amino acid N-terminus, a large central region of 4390 amino acids with multiple repeated units of about 128 amino acids in length, and the 1002 amino acid C-terminus. The central region seems to have antiparallel beta-strands connected by intervening loops. Several putative regulatory elements are clustered within the C-terminal region, including nuclear export localization signals, a leucine zipper, and potential phosphorylation sites for Akt1 and PKC. AHNAK is believed to be an important signalling molecule involved in a wide range of physiological activities and may be required for neuronal cell differentiation.. AHNAK also appears to influence b-adrenergic regulation of cardiac L-type Ca2+ channel function. Function: May be required for neuronal cell differentiation. Subunit: Interacts with DYSF; the interaction is direct and Ca(2+)-independent. Subcellular Location: Nucleus. Similarity: Contains 1 PDZ (DHR) domain. Database links: Entrez Gene: 79026 Human Entrez Gene: 66395 Mouse Entrez Gene: 191572 Rat Entrez Gene: 718802 Rhesus monkey Omim: 103390 Human SwissProt: Q09666 Human Unigene: 502756 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
AHNAK是由人类基因AHNAK编码的5890氨基酸蛋白。非内含型AHNAK基因位于人类染色体11q12上，具有三个主要结构区：251个氨基酸N-末端，4390个氨基酸的大中心区，多个重复单位长度约128个氨基酸，以及1002个氨基酸C-末端。中央区域似乎有反平行β链通过中介环连接。一些推测的调控元件聚集在C末端区域，包括核出口定位信号、亮氨酸拉链和Akt1和PKC的潜在磷酸化位点。AHNAK是一种重要的信号分子，参与多种生理活动，可能是神经细胞分化所必需的。AHNAK也似乎影响B型肾上腺素能调节心脏L型Ca2+通道功能。