ATF6 monoclonal antibody, clone 1-7
产品名称： ATF6 monoclonal antibody, clone 1-7
英文名称： ATF6 monoclonal antibody, clone 1-7
产品编号： MAB6762
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against partial recombinant ATF6.
- Immunogen:
- Recombinant His fusion protein corresponding to N-terminus human ATF6.
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Isotype:
- IgG2a, kappa
- Storage Buffer:
- In PBS (50% glycerol)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Publication Reference
- 1.
- Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1.
Yamamoto K, Sato T, Matsui T, Sato M, Okada T, Yoshida H, Harada A, Mori K.Dev Cell. 2007 Sep;13(3):365-76.
- 2.
- Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress.
Haze K, Yoshida H, Yanagi H, Yura T, Mori K.Mol Biol Cell. 1999 Nov;10(11):3787-99.
- 3.
- Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.
Hai TW, Liu F, Coukos WJ, Green MR.Genes Dev. 1989 Dec;3(12B):2083-90.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of human cell extracts using ATF6 monoclonal antibody, clone 1-7 (Cat # MAB6762).
Conversion of pATF6alpha (P) to pATF6alpha (N) in DTT- or tunicamycin-treated cells. Tm: 2 ug/mL tunicamycin (inhibitor of N-glycosylation). DTT : 1mM dithiothreitol (reducing reagent). The asterisk denotes an unglycosylated form of pATF6alpha (P).
ATF6alpha is constitutively expressed as pATF6alpha (P) (~90-kDa protein), and converted to pATF6alpha (N) (>50-kDa protein) in ER-stressed cells.
- Entrez GeneID:
- 22926
- Protein Accession#:
- P18850
- Gene Name:
- ATF6
- Gene Alias:
- ATF6A
- Gene Description:
- activating transcription factor 6
- Omim ID:
- 605537
- Gene Ontology:
- Hyperlink
- Gene Summary:
- ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules.[supplied by OMIM
- Other Designations:
- OTTHUMP00000025585,activating transcription factor 6 alpha
- Gene Pathway