NR3C1 polyclonal antibody
产品名称： NR3C1 polyclonal antibody
英文名称： NR3C1 polyclonal antibody
产品编号： PAB18124
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of NR3C1.
- Immunogen:
- A synthetic peptide corresponding to human NR3C1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This antibody is specific to NR3C1.
- Form:
- Liquid
- Purification:
- Affinity purification
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:500-1:1000)
ELISA (1:40000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Modulation of glucocorticoid receptor phosphorylation and transcriptional activity by a C-terminal-associated protein phosphatase.
Wang Z, Chen W, Kono E, Dang T, Garabedian MJ.Mol Endocrinol. 2007 Mar;21(3):625-34. Epub 2006 Dec 21.
- 2.
- p38 Mitogen-activated protein kinase (MAPK) is a key mediator in glucocorticoid-induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211.
Miller AL, Webb MS, Copik AJ, Wang Y, Johnson BH, Kumar R, Thompson EB.Mol Endocrinol. 2005 Jun;19(6):1569-83. Epub 2005 Apr 7.
- 3.
- Effects of aerobic training on pyruvate dehydrogenase and pyruvate dehydrogenase kinase in human skeletal muscle.
LeBlanc PJ, Peters SJ, Tunstall RJ, Cameron-Smith D, Heigenhauser GJ.J Physiol. 2004 Jun 1;557(Pt 2):559-70. Epub 2004 Mar 12.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of extracts from HeLa cells treated with PMA (125 ng/mL, 30 min), using NR3C1 polyclonal antibody (Cat # PAB18124).
Peptide "+" means "peptide blocking".
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NR3C1 polyclonal antibody (Cat # PAB18124).
Peptide "+" means "peptide blocking".
- Entrez GeneID:
- 2908
- Protein Accession#:
- P04150
- Gene Name:
- NR3C1
- Gene Alias:
- GCCR,GCR,GR,GRL
- Gene Description:
- nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- Omim ID:
- 138040
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. [provided by RefSeq
- Other Designations:
- nuclear receptor subfamily 3, group C, member 1
- Gene Pathway
- Related Disease
- Abortion, Habitual
- Addison Disease
- Adenoma
- Adrenal Gland Neoplasms
- Adrenal Hyperplasia, Congenital
- Adrenal hyperplasia, congenital
- Arthritis, Rheumatoid
- Asthma
- Asthma
- Atherosclerosis
- Atherosclerosis
- Bipolar Disorder
- Birth Weight
- Breast cancer
- Bronchiolitis, Viral
- Calcinosis
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Celiac Disease