SCN1B polyclonal antibody
产品名称： SCN1B polyclonal antibody
英文名称： SCN1B polyclonal antibody
产品编号： PAB13688
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of SCN1B.
- Immunogen:
- A synthetic peptide corresponding to amino acids at N-terminus of human SCN1B.
- Sequence:
- YENEVLQLEEDERFEGRVVWNGS
- Host:
- Rabbit
- Theoretical MW (kDa):
- 24.7
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- Identical to the related rat and mouse sequence.
- Form:
- Lyophilized
- Purification:
- Affinity purification
- Storage Buffer:
- Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
- Storage Instruction:
- Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Identification of an intra-molecular disulfide bond in the sodium channel ?]1-subunit.
Barbieri R, Baroni D, Moran O.Biochem Biophys Res Commun. 2012 Apr 6;420(2):364-7. Epub 2012 Mar 8.
- 2.
- Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture.
Chen C, Westenbroek RE, Xu X, Edwards CA, Sorenson DR, Chen Y, McEwen DP.J Neurosci. 2004 Apr 21;24(16):4030-42.
- 3.
- Genomic organization and chromosomal assignment of the human voltage-gated Na+ channel beta 1 subunit gene (SCN1B).
Makita N, Sloan-Brown K, Weghuis DO, Ropers HH, George AL Jr.Genomics. 1994 Oct;23(3):628-34.
- Entrez GeneID:
- 6324
- Gene Name:
- SCN1B
- Gene Alias:
- GEFSP1
- Gene Description:
- sodium channel, voltage-gated, type I, beta
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Voltage-gated sodium channels are essential for the generation and propagation of action potentials in striated muscle and neuronal tissues. Biochemically, they consist of a large alpha subunit and 1 or 2 smaller beta subunits, such as SCN1B. The alpha subunit alone can exhibit all the functional attributes of a voltage-gated Na+ channel, but requires a beta-1 subunit for normal inactivation kinetics.[supplied by OMIM
- Other Designations:
- sodium channel beta-1 subunit,sodium channel, voltage-gated, type I, beta polypeptide