MACC1 polyclonal antibody
产品名称： MACC1 polyclonal antibody
英文名称： MACC1 polyclonal antibody
产品编号： PAB16755
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of MACC1.
- Immunogen:
- A synthetic peptide corresponding to internal region 17 amino acids of human MACC1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- MACC1 controls Met: what a difference an Sp1 site makes.
Stein U, Smith J, Walther W, Arlt F.Cell Cycle. 2009 Aug;8(15):2467-9. Epub 2009 Aug 13.
- 2.
- Overexpression of MACC1 leads to downstream activation of HGF/MET and potentiates metastasis and recurrence of colorectal cancer.
Boardman LA.Genome Med. 2009 Apr 2;1(4):36.
- 3.
- MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis.
Stein U, Walther W, Arlt F, Schwabe H, Smith J, Fichtner I, Birchmeier W, Schlag PM.Nat Med. 2009 Jan;15(1):59-67. Epub 2008 Dec 21.
- Applications
- Western Blot (Tissue lysate)
- Western blot analysis of MACC1 in mouse liver tissue lysate with MACC1 polyclonal antibody (Cat # PAB16755) at (A) 1 and (B) 2 ug/mL .
- Entrez GeneID:
- 346389
- Protein Accession#:
- AJ313524
- Gene Name:
- MACC1
- Gene Alias:
- 7A5,SH3BP4L
- Gene Description:
- metastasis associated in colon cancer 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM
- Other Designations:
- putative binding protein 7a5