FITC标记的整合素β5抗体
产品名称： FITC标记的整合素β5抗体
英文名称： Anti-Integrin beta 5/FITC
产品编号： HZ-2094R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围：
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
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Rabbit Anti-Integrin beta 5/FITC Conjugated antibody
FITC标记的整合素β5抗体
| 英文名称 | Anti-Integrin beta 5/FITC |
| 中文名称 | FITC标记的整合素β5抗体 |
| 别 名 | Integrin beta 5; Integrin beta-5; integrin, beta 5; ITB5_HUMAN; Itgb5; AA475909; AI874634; beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A; [b]5B) FLJ26658; ITGB 5; ITGB5; |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, |
| 产品应用 | not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 86kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Integrin beta 5 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around 22 different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N terminal extracellular domain that binds the ECM ligand and a small C terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function. The integrin subunit beta 5 has only been associated with the alpha v subunit to form the alpha v beta 5 heterodimer. This integrin mediates cell adhesion to vitronectin and also recognizes fibronectin when the integrin is activated. This integrin is found in a variety of cells in most normal tissue. Function: Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. Subunit: Heterodimer of an alpha and a beta subunit. Beta-5 associates with alpha-V. Interacts with MYO10. Interacts with DAB2. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Belongs to the integrin beta chain family. Contains 1 PSI domain. Contains 1 VWFA domain. Database links: Entrez Gene: 3693 Human Entrez Gene: 16419 Mouse Entrez Gene: 257645 Rat Omim: 147561 Human SwissProt: P18084 Human SwissProt: O70309 Mouse Unigene: 536663 Human Unigene: 6424 Mouse Unigene: 16988 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
整合素是位于细胞表面的重要细胞外基质（ECM）受体蛋白。它们是由α和β跨膜糖蛋白亚基组成的六聚体。在自然界中发现了22种不同的整合素（不同的α/β亚基组合）。整合素通常存在于细胞表面的高浓度，但是，不像大多数其他细胞表面受体，它们结合配体具有非常低的亲和力。由于其弱的个体结合，整合素需要集群和绑定在组中，以有效地结合ECM。整合素结合许多不同的配体，包括层粘连蛋白。每个整合素是由一个大的N末端胞外域，结合ECM配体和一个小的C末端胞质结构域，介导与肌动蛋白细胞骨架和信号功能的相互作用。整合素亚基β5仅与αv亚基结合以形成αvβ5异二聚体。这种整合素介导细胞粘附到玻璃体连接蛋白，并且当整合素被激活时也能识别纤维连接蛋白。在大多数正常组织中，这种整合素存在于多种细胞中。