FITC标记的激活素受体相互作用蛋白1抗体
产品名称： FITC标记的激活素受体相互作用蛋白1抗体
英文名称： Anti-AIP1/FITC
产品编号： HZ-11705R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-AIP1/FITC Conjugated antibody
FITC标记的激活素受体相互作用蛋白1抗体
| 产品编号 | bs-11705R-FITC |
| 英文名称 | Anti-AIP1/FITC |
| 中文名称 | FITC标记的激活素受体相互作用蛋白1抗体 |
| 别 名 | Activin receptor interacting protein 1; Acvri1; Acvrinp1; ACVRIP1; AIP1; AIP 1; Aip-1; ARIP1; Atrophin 1 interacting protein 1; Atrophin 1 interacting protein A; Atrophin-1-interacting protein 1; Atrophin-1-interacting protein A; MAGI-2; MAGI2; MAGI2_HUMAN; Membrane associated guanylate kinase 2; Membrane associated guanylate kinase inverted 2; Membrane associated guanylate kinase WW and PDZ domain containing 2; Membrane associated guanylate kinase WW and PDZ domain containing protein 2; Membrane-associated guanylate kinase; Membrane-associated guanylate kinase inverted 2; S SCAM; SSCAM; WW and PDZ domain-containing protein 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 细胞膜受体 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 159kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human AIP1 (301-380aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: AIP1 (ASK-interacting protein 1), also known as DAB2IP (DAB2 interacting protein), is a 1,189 amino acid protein that localizes to both the membrane and the cytoplasm and contains one Ras-GAP domain, one PH domain and one C2 domain. Expressed at low levels in prostate tissue, AIP1 functions as a Ras GTPase-activating protein that interacts with ASK 1 and, via this interaction, disrupts the association of ASK 1 with an inhibitory 14-3-3 complex, thereby allowing free ASK 1 to function within the cell. AIP1 exists as multiple alternatively spliced isoforms and is down-regulated in prostate cancer tissue, suggesting a role in tumor suppression. Chromosomal aberrations in the gene encoding AIP1 are associated with acute myeloid leukemia (AML), implicating a role for AIP1 fusion proteins in tumorigenesis. Function: Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Subunit: Interacts (via its WW domains) with DRPLA. Interacts (via its second PDZ domain) with PTEN (via unphosphorylated C-terminus); this interaction diminishes the degradation rate of PTEN (By similarity). Interacts (via guanylate kinase domain) with DLGAP1 (By similarity). Interacts (via the PDZ domains) with GRIN2A, GRID2 and NLGN1 (By similarity). Interacts with CTNND2, CTNNB1, MAGUIN-1, ACVR2A, SMAD2 and SMAD3 (By similarity). Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity). May interact with HTR2A (By similarity). Interacts with IGSF9, RAPGEF2 and HTR4 (By similarity). Identified in a complex with ACTN4, CASK, IQGAP1, NPHS1, SPTAN1 and SPTBN1 (By similarity). Interacts with DDN. Subcellular Location: Cell junction, synapse, synaptosome (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Note=Membrane-associated in synaptosomes (By similarity). Tissue Specificity: Specifically expressed in brain. Similarity: Belongs to the MAGUK family. Contains 1 guanylate kinase-like domain. Contains 6 PDZ (DHR) domains. Contains 2 WW domains. Database links: Entrez Gene: 9863 Human Omim: 606382 Human SwissProt: Q86UL8 Human Unigene: 603842 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
AIP1（ASK相互作用蛋白1），也称为DAB2IP（DAB2相互作用蛋白），是定位于膜和细胞质中的1189个氨基酸蛋白，包含一个Ras间隙结构域、一个pH-结构域和一个C2结构域。AIP1在前列腺组织中以低水平表达，作为RAS GTP酶激活蛋白与ASK 1相互作用，并且通过该相互作用破坏ASK 1与抑制14-3-3复合物的结合，从而允许游离ASK 1在细胞内起作用。AIP1作为多个交替剪接的亚型存在，在前列腺癌组织中下调，提示肿瘤抑制的作用。AIP1基因的染色体畸变与急性髓系白血病（AML）有关，提示AIP1融合蛋白在肿瘤发生中的作用。