AR polyclonal antibody
产品名称： AR polyclonal antibody
英文名称： AR polyclonal antibody
产品编号： PAB12653
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of AR.
- Immunogen:
- A synthetic peptide corresponding to residues surrounding S210 of human AR.
- Host:
- Rabbit
- Theoretical MW (kDa):
- 110
- Reactivity:
- Dog, Human, Mouse, Rat
- Specificity:
- This antibody recognizes ~110 KDa of human AR.
- Form:
- Liquid
- Storage Buffer:
- In TBS, pH 7.2 (10% Proclin300)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Western Blot (0.1-1 ug/mL)
ELISA (0.01-0.1 ug/mL)
Immunoprecipitation (2-5 ug/mL)
Immunohistochemistry (2-5 ug/mL)
The optimal working dilution should be determined by the end user.
- Publication Reference
- 1.
- Androgen receptor gene knockout male mice exhibit impaired cardiac growth and exacerbation of angiotensin II-induced cardiac fibrosis.
Ikeda Y, Aihara K, Sato T, Akaike M, Yoshizumi M, Suzaki Y, Izawa Y, Fujimura M, Hashizume S, Kato M, Yagi S, Tamaki T, Kawano H, Matsumoto T, Azuma H, Kato S, Matsumoto T.J Biol Chem. 2005 Aug 19;280(33):29661-6. Epub 2005 Jun 16.
- Applications
- Application Image
- Western Blot
- Immunohistochemistry
- Immunoprecipitation
- ELISA
- Dot Blot (Peptide)
- enlarge
- Entrez GeneID:
- 367
- Gene Name:
- AR
- Gene Alias:
- AIS,DHTR,HUMARA,KD,NR3C4,SBMA,SMAX1,TFM
- Gene Description:
- androgen receptor
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq
- Other Designations:
- OTTHUMP00000023450,OTTHUMP00000061928,dihydrotestosterone receptor
- Gene Pathway
- Related Disease
- Abortion, Habitual
- Acne Vulgaris
- Adenocarcinoma
- Adrenal Hyperplasia, Congenital
- Alcoholism
- Alopecia
- Alzheimer Disease
- Alzheimer disease
- Androgen-Insensitivity Syndrome
- Angina Pectoris, Variant
- Antisocial Personality Disorder
- Arteriosclerosis
- Arthritis, Rheumatoid
- Asperger Syndrome
- Atherosclerosis
- Attention Deficit Disorder with Hyperactivity
- Autistic Disorder
- Azoospermia
- Biliary Tract Neoplasms