FITC标记的神经细胞特异性钙结合蛋白抗体
产品名称： FITC标记的神经细胞特异性钙结合蛋白抗体
英文名称： Anti-Hippocalcin/FITC
产品编号： HZ-11348R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Hippocalcin/FITC Conjugated antibody
FITC标记的神经细胞特异性钙结合蛋白抗体
| 产品编号 | bs-11348R-FITC |
| 英文名称 | Anti-Hippocalcin/FITC |
| 中文名称 | FITC标记的神经细胞特异性钙结合蛋白抗体 |
| 别 名 | BDR 2; BDR2; Calcium binding protein BDR 2; Calcium binding protein BDR2; Calcium-binding protein BDR-2; Hpca; HPCA_HUMAN; Neuron specific calcium binding protein hippocalcin; Neuron specific calcium-binding protein hippocalcin; Neuron-specific calcium-binding protein hippocalcin; P23K. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 结合蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Cow, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 22kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Hippocalcin |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Hippocalcin is a neuron-specific calcium-binding protein found primarily in the plasma membrane of brain and retinal tissue, with increased expression observed in hippocampal pyramidal cells. Through its calcium-dependent signal regulation, hippocalcin can both inhibit rhodopsin kinase and increase phospholipase D2 expression. In order to regulate kinase and phospholipase activity, hippocalcin must bind to the plasma membrane where it can then bind two calcium ions for use in signal regulation. The hippocalcin protein is highly conserved in mouse, rat and human tissue and has a suggested role in neural plasticity and associative memory by contributing to the survival of neurons during aging. The loss of hippocalcin expression is thought to contribute to age-related impairment of post-synaptic functions related to neuronal degradation. Function: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds two calcium ions. Tissue Specificity: Brain specific. Post-translational modifications: Myristoylation facilitates interaction with membranes. Similarity: Belongs to the recoverin family. Contains 4 EF-hand domains. Database links: Entrez Gene: 3208 Human Entrez Gene: 509772 Cow Entrez Gene: 15444 Mouse Entrez Gene: 29177 Rat Omim: 142622 Human SwissProt: Q4PL64 Cow SwissProt: P84074 Human SwissProt: P84075 Mouse SwissProt: P84076 Rat Unigene: 632391 Human Unigene: 384452 Mouse Unigene: 11019 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
海马钙蛋白是一种神经元特异性钙结合蛋白，主要存在于脑和视网膜组织的质膜中，在海马锥体细胞中观察到的表达增加。通过钙依赖性信号调节，海马钙素既能抑制视紫红质激酶，又能增加磷脂酶D2的表达。为了调节激酶和磷脂酶的活性，海马素必须结合到质膜上，然后它可以结合两个钙离子用于信号调节。在小鼠、大鼠和人体组织中，海马钙蛋白是高度保守的，并在神经可塑性和联想记忆中起到暗示作用，这有助于神经元在衰老过程中的存活。海马蛋白表达的丧失被认为有助于与神经元退化有关的突触后功能的年龄相关损害。